![Recombinant Human Anti-IAV HA Antibody [Clone: 3E1] - 500 ug](/web/image/product.product/11277/image_1024/%5B0708-PABC-312-500UG%5D%20Recombinant%20Human%20Anti-IAV%20HA%20Antibody%20%5BClone:%203E1%5D%20-%20500%20ug?unique=4f10371)
A recombinant Human antibody that can recognize IAV HA. 3E1 exhibited broad neutralizing activity against H1 and H5 subtype viruses in vitro and protected mice against H1N1 and H5N6 viruses in vivo by inhibiting the low pH-induced HA conformational rearrangement, hence blocking membrane fusion.
Specifications
- Host Species: Human
- Type: Human IgG
- Specificity: IAV HA
- Species Reactivity: H1N1 and H5N6
- Clone: 3E1
- Applications: ELISA, BLI, Neutralization
- Related Disease: Infectious disease
Product Property
- Purity: >95% as determined by analysis by SDS-PAGE
- Storage: Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
Application Notes: The antibody 3E1 has been reported in applications of Enzyme-linked Immunosorbent Assay, Biolayer interferometry, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names: IAV HA; Influenza A Virus Hemagglutinin; Hemagglutinin HA
References:
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.